Anticuerpos contra NF-kB para investigación en inmunología
NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
¿Which is the role of CCR5 in HIV infection?
HIV entry to macrophages and CD4+ T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 on the target cells' membrane and also with chemokine co-receptors such as CCR5. CCR5 is used by almost all primary HIV-1 isolates regardless of viral genetic subtype. CCR5-Δ32 is a 32-base-pair-deletion that has a heterozygote allele frequency of 10% and a homozygote frequency of 1% in Europe. CCR5-Δ32 do not express functional CCR5 receptors on their cell surfaces and are resistant to HIV-1 infection.
Endotelial cell markers
An organelle marker can be used to confirm protein localization and may reveal the potential role it plays in a variety of cellular processes. GeneTex organelle markers serve as powerful tools for immunofluorescence, they may also be used as western blot controls for fractionated cell lysates.
Interested in any of these topics? Click on the images and check the Genetex' related antibodies
Since January 2018, AbBcn, S.L. is participating in a H2020 project called “New Selenium-based Targeted Nanocapsules to treat Breast Cancer” (NEOSETAC) to develop a new treatment for breast cancer patients. On October 2nd, we attended to the fist workshop “Biomedical Applications of Nanotechnology” in Tulln, Austria, together with the other partners: ACIB, BOKU,ADSI, Karolinska Institutet, KAROLINSKA university Hospital, UAB and PRUAB.